Talk:Retinitis pigmentosa

"Interesting article"

Here's an interesting article for those involved with this article: "Chip improves vision, baffles scientists" - hope someone can find this useful and incorporate it. violet/riga (t) 21:14, 5 Apr 2005 (UTC)

Section entitled "Treatment"

I have removed the following paragraph from this section:

"Basic biological research by Bryan W. Jones and Robert E. Marc et. al. appears to indicate through comprehensive studies in human and animal models that retinal changes are dramatic and many current approaches to retinal rescue and prosthetics are based on a flawed and incomplete understanding of retinal degenerative processes. These studies and reviews for the first time are documenting the reality of retinal degenerative events and will better inform approaches to vision rescue strategies."

This information may be "from scientifically peer reviewed and accepted journals" but it is not readily obvious to the average Wiki reader why it should be included here. Please tie-in to the treatment of RP for inclusion. AED 06:01, 27 September 2005 (UTC)

Same pictures except colored

I was doing a project on Retinitis Pigmentosa and thought that I could point out that the same pictures on the wikipedia article are available in a colored format at http://blindness.org/content.asp?id=45. If an expert wikipedia has time, please change the images.

Treatments

While maybe not be considared a treatment per se, I have in the past (and will in the future once finances straiten out.), taken Vitimin A Daily. I belive it is sometming like 15,000 IUs. This slows the degernerative process.

Actually, you'd probably get liver failure and die. If your body needs A, it'll take it from foods. 71.34.217.109 02:09, 26 February 2006 (UTC)

The NIH seems to think that taking 15,000 IU's daily of vitamin A may slow the degenerative process : http://www.nei.nih.gov/news/clinicalalerts/alert-rp.asp

This discovery was made by the Harvard Medical School Berman-Gund Laboratory for the Study of Retinal Degenerations in Boston, situated at the Mass. Eye and Ear Infirmary. I will see if I can find the original paper. Here is one by the same laboratory in which they test Vitamin A supplementation in mice engineered to mimic a rhodopsin mutation (a common form of Retinitis pigmentosa). They produced the original research including human trials. They also determined that excess amounts of Vitamin E leads RP to speed up noticeably. Typical suggestions from ophthalmologists to patients therefore usually consist of "Take vitamin A supplements and avoid vitamin E." Berman-Gund has also proven that avoiding light preserves the morphology of the retina for longer periods of time, and slows the progression of loss of visual acuity.

• I found proof but not the paper: http://64.233.169.104/search?q=cache:fiXeSA3ifSEJ:www.nei.nih.gov/news/pressreleases/rppressrelease.asp+vitamin+A+supplementation+%2B+RP+%2B+berman&hl=en&ct=clnk&cd=1&gl=us

It is noted within the background information of the study that this work was done by Berman-Gund.

I have added a couple of links to summaries of the Berman-Gund papers to the main article. In case you need the original articles, you can request a copy of them to the corresponding author. BTW, safety of 15,000 IU vit. A has been tested[1]. C. Rivolta —The preceding unsigned comment was added by 130.223.204.146 (talk)

Inflammation?

The name, in particular the -itis suffix, implies that inflammation is involved. What is inflamed? Aaadddaaammm 07:56, 17 October 2006 (UTC)

Links

I don't know how to fix links, but in the second paragraph of the Diagnosis section "autosomal dominant" and "autosomal recessive" would be better links than "dominant" and "recessive". Both already have their own page on Wiki. 70.188.232.151 09:02, 8 March 2007 (UTC)cH

Diagnosis needs updating

Diagnosis needs updating. There are at least 341 known disease causing mutations across 13 genes for RP. Also, loci and genes are not the same thing. Loci refers to the specific location of a genetic abberation, e.g. RHOp23H, whereas gene referes to the entire protein coding region of the genome. 165.118.1.50 06:48, 8 October 2007 (UTC)

This is a small knit-pick, but a locus can also refer to a disease related gene, not just a mutation. This definition may not occur in many of the genetics texts, but the wording is used by many in the human genetics field. I agree that the article needs to be updated though, it's on my todo list. --Dpryan 15:44, 8 October 2007 (UTC)

what the...?

Their is a paragraph in the "See Also" section that doesn't belong there and is written very poorly and doesn't make sense. :-/ —Preceding unsigned comment added by 68.236.141.248 (talk) 19:32, 24 February 2008 (UTC)

It's called vandalism, it happens and I have reverted it. Thanks for pointing it out. --Dpryan (talk) 23:16, 24 February 2008 (UTC)

Tone

The sections headed "Signs", "Diagnosis" and "Genetics" read more like a medical textbook than an encyclopaedia and need to be rewritten to be comprehensible to the man on the street. I have wikilinked as much as I can but there are words such as "digenic" and "nonsyndromic" and phrases such as "the visual transduction cascade" which can't be linked and would have no obvious meaning to most people. Richerman (talk) 15:13, 23 April 2008 (UTC)

I have now put in more wikilinks and some explanations of terms which hopefully make things a bit clearer. Richerman (talk) 15:56, 15 May 2008 (UTC)

Rod-Cone Dystropy

I suggest to add the term rod-cone dystrophy. It is used to distinguish Retinitis pigmentosa (rod-cone dystrophy) from inversa retinitis pigmentosa (cone-rod dystrophy) —Preceding unsigned comment added by 151.53.240.221 (talk) 07:15, 20 May 2008 (UTC)

Introduction

The intro is poorly written. Would anyone like to make changes or shall I take care of it?

AriaNo11 (talk) 18:28, 19 June 2010 (UTC)

Make new article from Notable people with RP

Any objections to moving the list of notable RP sufferers to a separate article ? Rod57 (talk) 14:00, 25 June 2010 (UTC)

I could not verify that Kevin James has RP. I found one article mentioning that *his sister* has it. — Preceding unsigned comment added by Rssnkgp02 (talk • contribs) 02:14, 4 January 2011 (UTC)

No treatment or management section

Surely we need a section on treatment or management of RP - or at least say there are no treatments if that's the case. Rod57 (talk) 14:00, 25 June 2010 (UTC)

Found existing text (re vit A) in Genetics section so added 'treatment' heading, and also 'research' heading. Re the Vit A supplimentation - Can we say which types/causes of RP it works for, or what proportion of RP patients benefit ? Rod57 (talk) 14:23, 25 June 2010 (UTC)

Spoken article

There is a spoken file of old version of this article.

Is it lost or it was intentionally removed? I don't know. -- Andrew Krizhanovsky (talk) 17:50, 10 August 2011 (UTC)

Signs

A child displaying signs of RP may fall often, hit their heads on overhanging furniture or play structures, lose themselves in a darkened room or have difficulty locating objects. These signs are due to the reduced night vision and tunnel vision associated with RP. 198.103.167.20 (talk) 17:26, 18 October 2011 (UTC)

Please remove "suffering"

3 of my siblings have retinitis pigmentosa. . .they would object to the language "suffering with". They do not "suffer" because of RP, they adapt and thrive. Better language would be "people who have rp", "people experience RP", "people with rp".

Thanks for considering making the language more empowering and less disabling.

Colleen Erb — Preceding unsigned comment added by 205.196.128.3 (talk) 14:57, 9 June 2013 (UTC)

I was bold and removed the entire paragraph from the lead section. Several statements did not seem to me to have a neutral point of view and it did not seem to belong in the lead. Biolprof (talk) 04:50, 30 January 2014 (UTC)

Strengthening the "Treatment" Section

Hi all,

After spending a bit of time studying the manifestation and treatments available for retinitis pigmentosa, I feel like it is important to strengthen and substantiate the "treatment" section of the wikipedia article. While it currently focuses primarily on Argus II and vitamin treatments, information regarding additional therapies (such as induced pluripotent stem cell transplantation or embryonic stem cell transplantation) and alternative prosthetic devices would solidify the "Treatment" section. I am currently researching and gathering data regarding this topic, and hope to contribute significant information to strengthen the overall content of the article.

Meanwhile, here is an article that I find interesting regarding RP therapies and treatments. http://www.nature.com/news/curing-blindness-vision-quest-1.15875?WT.ec_id=NATURE-20140911

Course Link

Gathering Sources

Here are some sources that I will be using during my research. I will continue to add possible sources and develop a more structured bibliography. Please feel free to recommend any relevant sources and evaluate my list of article options that I have compiled thus far.

PubMed article, Retinitis Pigmentosa"

PubMed article providing an overview of disease presentation, pathology, and treatment

Orphanet Journal of Rare Diseases

Transplanting retinal pigment epithelium

Therapeutic techniques - prosthetic devices, gene therapy, stem cell

Mechanism of the rod degeneration and cell death

Thanks!

Carolynslu (talk) 19:51, 28 February 2015 (UTC)

References

Two thoughts on your references: several of them are a little on the old side (WP:MEDRS recommends using sources less than 5 years old ideally, and one of these is from 1999) and that the medpagestoday.com might not be a reliable source for medical articles. Are there recent articles that say cover the topic, especially review articles? (You can specify date ranges in Google Scholar or other search tools.) If there are, then they are likely to have updated information. If they aren't, then it's worth wondering why not - this is a significant medical topic, it's unlikely that promising areas would simply have fallen by the wayside. Ian (Wiki Ed) (talk) 21:54, 2 March 2015 (UTC)

There were a lot of reveiw articles on RP around 2000-2005 (Try here for a list). More recent review articles tend to be much more specific as the science drills deeper and fragments. This is a highly cited article and good for background, but a bit dated on treatment. Carolynslu, I can help you get access to any of these that our library does not have. Just let me know. Biolprof (talk) 03:51, 5 March 2015 (UTC)

Thank you for the input Biolprof and Ian (Wiki Ed). I found a few more PubMed articles that seem to cover more recent research. I am still browsing for some articles that further address RP genetics. I will continue to compile references and resources throughout this project, and will update my source list accordingly. Carolynslu (talk) 15:39, 5 March 2015 (UTC)

Project Goals

Here are a list of some my project goals while reconstructing the Retinitis Pigmentosa Wikipedia article

1. Formulating an outline (when we add future edits, the outline can remain some sort of a framework or foundation)
2. Adding images relating to diagnostics, symptoms (bone spicules, fundus, etc), and treatment (prosthetic devices)
3. Identifying and removing/altering any sentences which may appear verbatim on other web pages (The first sentence of the RP Wikipedia article appears on a few other websites)
4. Strengthening the current article with up to date research
5. Providing a more organized article
6. Filling in gaps that are relevant sections for medical articles

I will continue to update this list of goals as my research continues!

Carolynslu (talk) 02:54, 10 March 2015 (UTC)

Comments from VarunS93

As a part of assignment I will be peer-reviewing an article used in the article about [[Retinitis pigmentosa]. The article in question is a comprehensive review about Retinitis pigmentosa and covers a lot of the more basic and some advanced information about the disorder. The article can be found here: [2]

Overall, the review done in this article for the disorder is very well written. It encompasses a lot of the basic facts that are required to understand Retinitis pigmentosa. In addition, it goes into a lot of detail about the causes and pathology of retinitis pigmentosa.

• Portions of the article do represent the cited source well.
• While the material can be dense in the article it is important to phrase it in a way that is easily understood by the wide audience that uses Wikipedia. The article is well put together but in some parts may be too technical for the general Wikipedia viewer.
• Anytime an article like this is cited it is hard to paraphrase since most of the statements are purely factual. There is little prose in these articles that can be paraphrased in such a way that it is not purely copied and pasted. Use of this article, however, seems to be properly paraphrased.
• There do not seem to be very many gaps in the knowledge of the article, it is a pretty comprehensive review.
• Article structure is well incorporated into the Retinitis pigmentosa page. There is a good mix of fact and prose intermixed, making for an enjoyable reading experience.

Overall, the article is very critical in the future development of the Retinitis Pigmentosa page. It has a lot of great information that is used. Good choice is picking such a comprehensive review article.

Peer Review #2

Hey Carolyn, your article looks really well done. I am really enjoying all the information you have gathered, pictures, and tables that you were able to find. They contribute really well to the overall flow and ease of information.

• Your article does a good job of presenting information from cited sources and everything seems to be well paraphrased.
• I'm not sure if the too technical banner at the top of the page still applies but it may be due to some of the information in the article, especially in the genetics section, maybe some of it could be reworded to make it a little easier for those without a large scientific background to more easily understand.
• I think overall the article follows the style guidelines really well, looks like any other good wikipedia article that I have seen.
• I think the information in each subsection is more than adequate and there don't seem to be any gaps in knowledge that I know of, but then again I'm not an expert on RP. However, if i was looking to Wikipedia for information on the topic I think you've done a good job in your subsections covering all the major topics.
• Prose and sentence structure is all good, information flows well from one point to another.
• Good linking to other articles.

Again really well done, the article really has taken a good shape for the final form. VarunS93 (talk) 23:07, 27 April 2015 (UTC) VarunS93 (talk) 22:59, 27 April 2015 (UTC) VarunS93 (talk) 20:44, 8 April 2015 (UTC)

— Preceding unsigned comment added by VarunS93 (talk • contribs) 20:34, 8 April 2015 (UTC)

Research on Melanopsin and ipRGCs

Lately there's been a lot of research on the photopigment melanopsin (peak sensitivity 480 mn). We have it on our ipRGCs (Intrinsically photosensitive retinal ganglion cells). (It's also in our skin and brains.) In one study, two elderly Japanese people who were profoundly blind with Retinitis pigmentosa were found to have pupil response that peaked at 480 nm. There is also indication that such people can sense the presence or absence of light. In blind mice with no rods or cones, they've been able to amp up the Melanopsin and get them to pass simple vision tests. Zyxwv99 (talk) 21:09, 18 October 2015 (UTC)

treatment history - perhaps

http://articles.latimes.com/1993-02-28/news/mn-231_1_retinitis-pigmentosa

Notable case - perhaps. (also mentioned, briefly, in http://history.nasa.gov/sp482.pdf on page 51 of the pdf, p46 of the printed book - NASA SP-482 -THE IMPACT OF SCIENCE ON SOCIETY - James Burke - Jules Bergman - Isaac Asimov ). 213.222.172.165 (talk) 23:15, 5 July 2016 (UTC).

Classification

Retinitis pigmentosa has an array of identifying features. These include night blindness, a decrease in peripheral vision, narrowing of the retinal vessels, and the movement of pigment from disrupted retinal pigment epithelium into the retina, forming clumps. These darker clumps of pigment are the hallmark of the disorder. Mp214 (talk) 17:59, 25 April 2018 (UTC)

Okay? Doc James (talk · contribs · email) 01:14, 26 April 2018 (UTC)

Nature paper and CNN article

This just arrived by way of CNN: Blind man has sight partially restored after 40 years. The CNN article reference a newly published paper from Nature Medicine journal: Partial recovery of visual function in a blind patient after optogenetic therapy.

Jeffrey Walton (talk) 04:00, 4 June 2021 (UTC)